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The initial responses to endotoxemia are detectable in the microcirculation as a microvascular inflammatory response characterized by activation of the endothelium stimulating these cells from their normal anticoagulant state to a procoagulant state with increased adhesivenes for leukocytes and platelets. Concomitantly, arteriolar tone is lost and reactivity to a variety of agonists is modified....
Objective: To examine localisation of tumour necrosis factor (TNFα) and transforming growth factor β (TGFβ) mRNA synthesis in human coronary artery atheromatous plaques, to explore how synthesis of these cytokines relates to distribution of macrophages and smooth muscle cells, and to correlate this with plaque micro-environments. Method: In situ hybridisation with digoxigenin-labelled sense and anti-sense...
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