Monthly weights of 175 residents were reviewed during the four month study. Eighty three residents lost weight and became the subjects for the study. Sixty one residents had significant weight loss during one out of the four months. Twenty two residents has significant weight loss in two or more months during the study. The pre-selected variables were gathered through a chart review on the subjects which had significant unintentional weight loss. Descriptive statistics and frequencies were used to compare the variables. Chi-square (P=<.05) was used to determine the relationships between monthly weight loss and the independent variables. Eleven combinations were found significant toward weight loss in the 61 subjects who experienced weight loss in one month: puree diet and missing teeth (P=0.004); regular diet and dentures (P=0.004); puree diet and assistance (P=0.000); regular diet and independent (P=0.000); lounge and assistance (P=0.000); puree diet and lounge (P=0.000); regular diet and dining room (P=0.000); anxiety and paxil (P=0.000); depression and paxil (P=0.008); dementia and depakote (P=0.03); and depression and personal room (P=0.048). Five combinations were found significant in the 22 subjects with repeated weight loss: independence and personal room (P=0.002); supervision and dining room (P=0.002); independence and regular diet (P=0.000); assistance and puree diet (P=0.000); and puree diet and missing teeth (P=0.023). This study has revealed that combinations of clinical indicators contribute toward weight loss in nursing home residents. The majority of the indicators are treatable through therapy and proper screening and re-screening techniques. More research is needed on functional skills, dental health, cognitive diagnoses, psychotropic medications, and reasons behind dining alone.