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A sharp rise in the incidence of inflammatory bowel disease (IBD) has been observed in the western world since the early 1950s. The increase in the incidence of ulcerative colitis preceded the increase in the incidence of Crohn's disease by about 10-15 years. In high-incidence areas, a female preponderance at a young age (20-40 years) is observed in Crohn's disease, whereas in ulcerative colitis male...
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