After partial substitution of V 2 O 5 in V 2 O 5 –WO 3 /TiO 2 by metal oxide (M x O y , M=Fe, Co, Ni, Cu, Sr, La, and Ce), the NO conversions for the M x O y –V 2 O 5 –WO 3 /TiO 2 catalysts (M-VW) showed the following sequence: Co–VW>Fe–VW>Sr-VW≈Ce-VW≈La-VW>VW>Ni-VW>Cu-VW. The reduction activities for almost all the M-VW catalysts were enhanced at reaction temperature >400°C, but only the Co-VW catalyst showed an increased activity at temperature <400°C. Among the M-VW catalysts tested, the Co-VW sample had the highest catalytic activity with a temperature range of 300–550°C for more than 90% NO removal at a GHSV of 60000h −1 . Moreover, the Co-VW sample exhibited high space-velocity, H 2 O and SO 2 resistance, and low N 2 O yield. Co partial substitution for V in the VW led to more Lewis acid sites and Brønsted acid sites, and an obvious increase in the ratio of the adsorbed oxygen to the lattice oxygen from 12.74% for VW to 36.73% for Co-VW. The increased adsorbed oxygen and Lewis and Brønsted acid sites contributed to the improved SCR activity of the Co-VW sample.