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The sperm acrosome reaction (AR) is a regulated exocytotic process required for gamete fusion. It depends on an increase in [Ca2+]i mediated by Ca2+ channels. Although calmodulin (CaM) has been reported to regulate several events during the AR, it is not known whether it modulates sperm Ca2+ channels. In the present study we analyzed the effects of CaM antagonists W7 and trifluoroperazine on voltage-dependent...
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