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The acrosome is a membrane-limited granule that overlies the nucleus of the mature spermatozoon. In response to physiological or pharmacological stimuli, sperm undergo calcium-dependent exocytosis termed the acrosome reaction, which is an absolute prerequisite for fertilization. Protein tyrosine phosphorylation and dephosphorylation are a mechanisms by which multiple cellular events are regulated...
The TRPC cation channel family has been implicated in receptor- or phospholipase C (PLC)-mediated Ca 2+ entry into animal cells. These channels are present in mammalian sperm and are assigned a role in ZP3-evoked Ca 2+ influx that drives acrosome reactions. However, the mechanisms controlling channel activity and coupling Ca 2+ entry through these channels to cellular responses...
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