This study investigates both the efficacy and selectivity temperature responsive of poly(N-isopropylacrylamide) PNIPAM as a flotation collector. The results of this study showed that charged poly(N-isopropylacrylamide) polymers selectively increased both the probability particle/bubble attachment as well as the floatability of coarse alumina and quartz particles respectively. These results provide a basis for considering PNIPAM as both an effective and selective collector in a flotation system. Coupled with previous studies that demonstrate the efficacy of PNIPAM as a flocculant in mineral suspensions, these results clearly demonstrate the potential use of PNIPAM as a dual function reagent which acts as both selective flotation collector and flocculant in the flotation of ultrafine particles.