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The response pattern of specific antibodies to the microfilarial sheath (sheath-Ab) of the mosquito-borne filarial parasite Wuchereria bancrofti was investigated in individuals from two East African communities with different levels of endemicity. Individuals from both communities presented a strong inverse relationship between positivity for sheath-Ab and being positive for microfilariae (mf) and...
To evaluate the effect of multiple rounds of annual single dose of DEC (6mg/kg) or albendazole (400mg) given alone or in combination on Wuchereria bancrofti microfilaraemia, anti-filarial IgG1 and IgG4 and antigenaemia.A total of 170 participants were randomly assigned to albendazole (n=62), DEC (n=54), and DEC plus albendazole (DEC/ALB) combination (n=54). Blood samples were collected at pre-treatment...
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