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The aim of this study was to evaluate whether abdominal myomectomy could be a choice for patients with symptomatic fibroids above the age of 48 years, who wish to get hormonal replacement therapy and desire to retain their uterus.We performed 504 abdominal myomectomies between 1990 and 2004. The mean age was 33±4.09 years, 9 (1.8%; 9/504) patients were above 48 years and 6 (1.19%; 6/504) of them requested...
The study in ovariectomized (Ovx) rats, as a model of menopausal status, of the effects of melatonin (M) and/or estradiol (E), associated or not with food restriction, on body weight (BW) and serum leptin levels.Female SD rats (200–250g) were Ovx and treated with E, M, E+M or its diluents. Control sham-Ovx rats were treated with E–M diluents. After 7 weeks being fed ad libitum, the animals were exposed...
Tibolone is a tissue selective compound with estrogenic, androgenic and progestogenic properties in classical bioassays. It is used for alleviation of menopausal symptoms and for osteoporosis prophylaxis in postmenopausal women. Only few data are available regarding the effects of tibolone on the cardiovascular system. We investigated therefore the in vitro effects of tibolone and its metabolites...
We conducted this study to examine premenopausal risk factors associated with premature ovarian failure (POF) and early menopause (EM) among Korean women.A 73% of total women aged 30–69 at four districts in the KMCC (Korean Multi-center Cancer Cohort) was participated in this study during 2002–2003. We selected 137 POF and 281 EM cases who had menopause before age 40 and at age 40–44, respectively,...
The aim of this study was to investigate factors associated with menopausal symptoms and their relationship with the quality of life among Turkish women.This is a cross-sectional study and included 886 women. Data were collected with a questionnaire including questions about demographics and independent variables tested, the Menopause Symptom Checklist and The MOS 36-Item Short Form Health Survey...
Burning mouth syndrome associated to vulvodynia (Vulvostomatodynia) is a rare condition and is often difficult to diagnose and treat. Tongue, lips, vestibule and others mucosal sites may be affected by a tiresome burning sensation, especially in menopausal and postmenopausal women. Patients seldom report genital symptoms to the dentist and dentists do not generally investigate about genital symptoms...
Acute hyperinsulinemia produces sympathetic activation, vasodilation, and cardiovascular changes in healthy young men. Postmenopausal period is accompanied by sympathetic, vascular and cardiovascular changes. Nevertheless, the effects of acute insulin infusion were not known in postmenopausal women. To study this aspect, 26 postmenopausal healthy women were submitted to an euglycemic hyperinsulinemic...
Weight gain and the associated increased risk of coronary artery disease are associated with the postmenopausal period. However, moderate intensity physical activity may be cardioprotective in this period. Australian women remain predominately sedentary despite the health benefits of regular exercise. Self-efficacy is an important predictor of exercise behaviour influencing exercise adoption when...
Increasing research suggested that Cimicifugae rhizoma might be protective against osteoporosis. In this study, we investigated the effects of three cycloartane-type triterpenoids isolated from Cimicifugae rhizoma, cimicidol-3-O-β-d-xyloside (1), cimicidanol-3-O-β-d-xyloside (2) and acetylacteol-3-O-β-d-xyloside (3) on bone resorption in vitro and bone loss in ovariectomized (OVX) mice.The activities...
To investigate the efficacy-safety balance of the isopropanolic extract of Actaea (=Cimicifuga) racemosa (iCR, Remifemin ® ) in comparison with tibolone in Chinese women with climacteric complaints.The randomized, double-blind, controlled 3-month study in 5 centers of 3 cities in China enrolled 244 menopausal patients aged 40–60 years and with a Kupperman Menopause Index (KMI)≥15. The participants...
The purpose of this study was to investigate the relationship between endogen sex hormone levels and myocardial performance in two different phases of menstrual cycle.The relationships between cardiac performance and sex hormone levels in menstrual cycle have not yet been clearly identified.Twenty-seven women at the age of 19–42 years (mean 24.11±6.02) with regular menstrual cycles (28–31 days) were...
To evaluate within the Traditional Chinese Medicine (TCM) setting, the effect of CHM—formulae on menopausal symptoms.A double-blind and double-dummy randomised placebo-controlled trial.Between February and June 2002 and June and October 2004, 31 peri- and postmenopausal Dutch women were recruited to complete 12 weeks of treatment with either CHM formulae (n=10), HRT (n=11) or placebo (n=10) medications...
Sarcopenia, the loss of muscle mass with age, has a great impact on physical function, and especially in postmenopausal women, who experience a greater decline in muscle strength than do men of similar age. Conventional hormone replacement therapy (HRT) may diminish this loss of muscle strength and may even increase muscle strength. However, HRT is not currently promoted for this indication because...
The historical origins of the modern concept of a “male climacteric” have hitherto been traced to the late 19th and early 20th centuries. Based on a careful scrutiny of early modern and 19th-century sources, this paper shows that the concept goes back much further, however. It evolved from the ancient notion of critical “climacterical years” which recurred every 7th year throughout human life and...
Kidney (renal cell) cancer accounts for approximately 3–4% of all new cases of primary cancer diagnosed in the United States. A relationship between kidney cancer and female reproductive factors has been hypothesized but supporting evidence is inconsistent. Our objectives were to explore the relationship between female reproductive factors and kidney cancer and identify independent risk factors related...
Deciding whether to treat postmenopausal women suffering from climacteric symptoms with Continuous Combined Hormone Replacement Therapy (CCHRT) has become increasingly difficult after the release of the Women's Health Initiative results. As a result, development of alternatives to CCHRT is required. Tibolone, which is a synthetic steroid that has estrogenic, progestogenic and androgenic properties,...
To evaluate the effects of an estrogen-reduced, continuous-combined hormone therapy preparation (HT) containing 1mg estradiol valerate (1EV) and 2mg dienogest (2DNG) on the number of moderate and severe hot flushes.This study compared the effects of an oral continuous-combined HT containing 1mg EV and 2mg DNG (1EV/2DNG) with those of placebo. The planned treatment duration was 12 weeks. Data were...
Vitamin D is a hormone that controls phosphorus, calcium, and bone metabolism and neuromuscular function. Vitamin D synthesis is a process in which the skin, liver, and kidney are sequentially involved. The vitamin D pool is completed by the amount taken with food and supplements. Vitamin D deficiency causes osteopenia, precipitates and exacerbates osteoporosis, causes a painful disease, osteomalacia,...
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