Although cryoballoon based catheter ablation is an effective therapeutic option in atrial fibrillation (AF), a significant amount of patients failed to remain in sinus rhythm at long term follow-up. Appropriate selection of patients for catheter ablation reduces unnecessary interventions and prevents complications related with catheter ablation. The purpose of our study is to propose a new scoring system in the prediction of recurrence after AF ablation with cryoballoon.A total of 236 patients (54% male, age 54.6±10.45years and 79.6% paroxysmal) with symptomatic AF underwent an index cryoablation. The first 3months after AF ablation is defined as blanking period. Predictors of AF recurrence after cryoablation were analyzed with multivariate Cox regression analysis. BASE-AF 2 score [acronym stands for Body mass index >28kg/m 2 (1); Atrial dilatation >40mm (1); current Smoking (1); Early recurrence (1); duration of AF history >6years (1) and non-paroxysmal type (1) of AF] is identified by the total number of significant predictors of recurrence in each patient (range=0–6).At median 20 (range: 12–30) months follow-up, 74.5% of the patients were free from AF recurrence. Of these patients, 64 (27.1%) patients had a BASE-AF 2 score of ≥3. Patients with AF recurrence had a higher mean BASE-AF 2 score (3.27±0.82 vs. 1.1±0.95, p<0.001) compared to patients without AF recurrence. ROC analysis showed that a BASE-AF 2 score of ≥3 well predicted AF recurrence with a sensitivity of 80.8% and a specificity of 91.6% (AUC=0.94; 95% CI: 0.89–0.97, p<0.001). A BASE-AF 2 score of ≥3 was found to be an independent predictor of AF recurrence (HR: 3.34, 95% CI: 2.34–4.76, p=0.001).BASE-AF 2 , which was identified as a new scoring system, has well predicted AF recurrence and could be helpful in selecting appropriate patients for interventional strategy.