Literature suggests that CF may be associated with developing cataracts; however, the true prevalence of cataracts in CF patients is unknown since a cataract may remain undetected until vision is impaired. This analysis characterizes cataract frequency in patients homozygous for the F508del-CFTR mutation. Analyses focused on CF patients aged ≥12 y and homozygous for the F508del mutation who were screened for participation in the lumacaftor/ivacaftor phase 3 TRAFFIC and TRANSPORT studies, and who underwent comprehensive slit lamp lens examinations by a licensed ophthalmologist at screening. Frequency and characteristics (type and location) of cataracts were assessed, and risk factors for cataracts were evaluated in a multivariate analysis. In total, 1302 patients underwent a slit lamp exam, of whom 101 (7.8%; 95% CI: 6.3–9.2) had a cataract detected. Among patients with cataracts, 91.1% were newly diagnosed, 69.3% had bilateral cataracts, and the most common cataract location was cortical (42.6%). Approximately 11% of all cataract findings were consistent with congenital lens opacity morphology. Cataract frequency was 6.1% in the youngest age group (12–18 y; n = 407); patients ±46 y had the highest frequency (24.1%; n = 54). In the multivariate analyses including age, sex, and medical history variables, older age was the only independent predictor of cataracts. This analysis revealed a 7.8% prevalence of cataracts in CF patients ≥12 y undergoing comprehensive eye exams; most cataracts were previously undetected. While frequency was highest in patients who were older in age, cataracts were also diagnosed in patients <18 y.