Biochimica et Biophysica Acta (BBA) - Biomembranes

Items from 1 to 16 out of 16 results

article

Mechanisms of conotoxin inhibition of N-type (Cav2.2) calcium channels

David J. Adams, Géza Berecki

BBA - Biomembranes > 2013 > 1828 > 7 > 1619-1628

N-type (Ca _v 2.2) voltage-gated calcium channels (VGCC) transduce electrical activity into other cellular functions, regulate calcium homeostasis and play a major role in processing pain information. Although the distribution and function of these channels vary widely among different classes of neurons, they are predominantly expressed in nerve terminals, where they control neurotransmitter...

article

Structure and function of the β subunit of voltage-gated Ca2+ channels

Zafir Buraei, Jian Yang

BBA - Biomembranes > 2013 > 1828 > 7 > 1530-1540

The voltage-gated Ca ²⁺ channel β subunit (Ca _v β) is a cytosolic auxiliary subunit that plays an essential role in regulating the surface expression and gating properties of high-voltage activated (HVA) Ca ²⁺ channels. It is also crucial for the modulation of HVA Ca ²⁺ channels by G proteins, kinases, Ras-related RGK GTPases, and other proteins. There are indications...

article

Cav1.3 and Cav1.2 channels of adrenal chromaffin cells: Emerging views on cAMP/cGMP-mediated phosphorylation and role in pacemaking

D.H.F. Vandael, S. Mahapatra, C. Calorio, A. Marcantoni, more

BBA - Biomembranes > 2013 > 1828 > 7 > 1608-1618

Voltage-gated Ca ²⁺ channels (VGCCs) are voltage sensors that convert membrane depolarizations into Ca ²⁺ signals. In the chromaffin cells of the adrenal medulla, the Ca ²⁺ signals driven by VGCCs regulate catecholamine secretion, vesicle retrievals, action potential shape and firing frequency. Among the VGCC-types expressed in these cells (N-, L-, P/Q-, R- and T-types), the...

article

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article

CaV1.1: The atypical prototypical voltage-gated Ca2+ channel

Roger A. Bannister, Kurt G. Beam

BBA - Biomembranes > 2013 > 1828 > 7 > 1587-1597

Ca _V 1.1 is the prototype for the other nine known Ca _V channel isoforms, yet it has functional properties that make it truly atypical of this group. Specifically, Ca _V 1.1 is expressed solely in skeletal muscle where it serves multiple purposes; it is the voltage sensor for excitation–contraction coupling and it is an L-type Ca ²⁺ channel which contributes to a form...

article

Regulation of voltage-dependent calcium channels by RGK proteins

Tingting Yang, Henry M. Colecraft

BBA - Biomembranes > 2013 > 1828 > 7 > 1644-1654

RGK proteins belong to the Ras superfamily of monomeric G-proteins, and currently include four members — Rad, Rem, Rem2, and Gem/Kir. RGK proteins are broadly expressed, and are the most potent known intracellular inhibitors of high-voltage-activated Ca ²⁺ (Ca _V 1 and Ca _V 2) channels. Here, we review and discuss the evidence in the literature regarding the functional mechanisms,...

article

What can naturally occurring mutations tell us about Cav1.x channel function?

Thomas Stockner, Alexandra Koschak

BBA - Biomembranes > 2013 > 1828 > 7 > 1598-1607

Voltage-gated Ca ²⁺ channels allow for Ca ²⁺ -dependent intracellular signaling by directly mediating Ca ²⁺ ion influx, by physical coupling to intracellular Ca ²⁺ release channels or functional coupling to other ion channels such as Ca ²⁺ activated potassium channels. L-type Ca ²⁺ channels that comprise the family of Ca _v 1 channels are expressed...

article

T-type Ca2+ channels in absence epilepsy

Eunji Cheong, Hee-Sup Shin

BBA - Biomembranes > 2013 > 1828 > 7 > 1560-1571

Low-voltage-activated T-type Ca ²⁺ channels are highly expressed in the thalamocortical circuit, suggesting that they play a role in this brain circuit. Indeed, low-threshold burst firing mediated by T-type Ca ²⁺ channels has long been implicated in the synchronization of the thalamocortical circuit. Over the past few decades, the conventional view has been that rhythmic burst firing...

article

The α2δ subunits of voltage-gated calcium channels

Annette C. Dolphin

BBA - Biomembranes > 2013 > 1828 > 7 > 1541-1549

Voltage-gated calcium channels consist of the main pore-forming α ₁ subunit, together, except in the case of the T-type channels, with β and α ₂ δ and sometimes γ subunits, which are collectively termed auxiliary or accessory subunits. This review will concentrate on the properties and role of the α ₂ δ subunits of these channels. These proteins are largely extracellular, membrane-associated...

article

Alternative splicing: Functional diversity among voltage-gated calcium channels and behavioral consequences

Diane Lipscombe, Arturo Andrade, Summer E. Allen

BBA - Biomembranes > 2013 > 1828 > 7 > 1522-1529

Neuronal voltage-gated calcium channels generate rapid, transient intracellular calcium signals in response to membrane depolarization. Neuronal Ca _V channels regulate a range of cellular functions and are implicated in a variety of neurological and psychiatric diseases including epilepsy, Parkinson's disease, chronic pain, schizophrenia, and bipolar disorder. Each mammalian Cacna1 gene has...

article

T-type calcium channels in burst-firing, network synchrony, and epilepsy

Stuart M. Cain, Terrance P. Snutch

BBA - Biomembranes > 2013 > 1828 > 7 > 1572-1578

Low voltage-activated (LVA) T-type calcium channels are well regarded as a key mechanism underlying the generation of neuronal burst-firing. Their low threshold for activation combined with a rapid and transient calcium conductance generates low-threshold calcium potentials (LTCPs), upon the crest of which high frequency action potentials fire for a brief period. Experiments using simultaneous electroencephalography...

article

Control of low-threshold exocytosis by T-type calcium channels

Norbert Weiss, Gerald W. Zamponi

BBA - Biomembranes > 2013 > 1828 > 7 > 1579-1586

Low-voltage-activated (LVA) T-type Ca ²⁺ channels differ from their high-voltage-activated (HVA) homologues by unique biophysical properties. Hence, whereas HVA channels convert action potentials into intracellular Ca ²⁺ elevations, T-type channels control Ca ²⁺ entry during small depolarizations around the resting membrane potential. They play an important role in electrical...

article

Advances in voltage-gated calcium channel structure, function and physiology

Gerald W. Zamponi, Terrance P. Snutch

BBA - Biomembranes > 2013 > 1828 > 7 > 1521

article

Modulation of low-voltage-activated T-type Ca2+ channels

Yuan Zhang, Xinghong Jiang, Terrance P. Snutch, Jin Tao

BBA - Biomembranes > 2013 > 1828 > 7 > 1550-1559

Low-voltage-activated T-type Ca ²⁺ channels contribute to a wide variety of physiological functions, most predominantly in the nervous, cardiovascular and endocrine systems. Studies have documented the roles of T-type channels in sleep, neuropathic pain, absence epilepsy, cell proliferation and cardiovascular function. Importantly, novel aspects of the modulation of T-type channels have been...

article

Regulation of CaV2 calcium channels by G protein coupled receptors

Gerald W. Zamponi, Kevin P.M. Currie

BBA - Biomembranes > 2013 > 1828 > 7 > 1629-1643

Voltage gated calcium channels (Ca ²⁺ channels) are key mediators of depolarization induced calcium influx into excitable cells, and thereby play pivotal roles in a wide array of physiological responses. This review focuses on the inhibition of Ca _V 2 (N- and P/Q-type) Ca ²⁺ -channels by G protein coupled receptors (GPCRs), which exerts important autocrine/paracrine control...

article

Calcium channels and migraine

Daniela Pietrobon

BBA - Biomembranes > 2013 > 1828 > 7 > 1655-1665

Missense mutations in CACNA1A, the gene that encodes the pore-forming α ₁ subunit of human voltage-gated Ca _V 2.1 (P/Q-type) calcium channels, cause a rare form of migraine with aura (familial hemiplegic migraine type 1: FHM1). Migraine is a common disabling brain disorder whose key manifestations are recurrent attacks of unilateral headache that may be preceded by transient neurological...

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Number:
7
Volume:
1828
Year:
2013

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Keywords

CALCIUM CHANNEL (5)
AUXILIARY SUBUNIT (2)
CHANNELOPATHY (2)
G PROTEIN COUPLED RECEPTOR (2)
T-TYPE CA2+ CHANNEL (2)
ABSENCE EPILEPSY (1)
ALPHA2DELTA (1)
ARACHIDONIC ACID (1)
BK AND SK CHANNELS (1)
BURST FIRING (1)
BURST-FIRING (1)
CALMODULIN KINASE II (1)
CAMP/PKA AND CGMP/PKG MODULATION (1)
CATECHOLAMINE RELEASE (1)
CAV1.1 (1)
CAV3 (1)
CEREBRAL CORTEX (1)
CHRONIC PAIN (1)
DIHYDROPYRIDINE RECEPTOR (DHPR) (1)
DISEASE (1)
ELECTROPHYSIOLOGY (1)
ENDOCYTOSIS (1)
EPILEPSY (1)
EXCITATION-COUPLED CA2+ ENTRY (ECCE) (1)
EXCITATION–CONTRACTION (EC) COUPLING (1)
EXOCYTOSIS (1)
GABAB RECEPTOR (1)
GEM (1)
GΒΓ (1)
HOMOLOGY MODELING (1)
ION CHANNEL (1)
L-TYPE (1)
L-TYPE CALCIUM CHANNEL (1)
LOW-THRESHOLD CALCIUM POTENTIAL (1)
LOW-THRESHOLD SPIKE (1)
MIGRAINE (1)
MORPHINE (1)
MU-OPIOID RECEPTOR (1)
N-TYPE CALCIUM CHANNEL (1)
NEURAL NETWORK (1)
NEURON (1)
NEUROPATHIC PAIN (1)
NOCICEPTOR (1)
OSCILLATIONS (1)
PIP2 (1)
PROTEIN KINASE (1)
RAD (1)
REM (1)
REM2 (1)
RGK PROTEIN (1)
RHO KINASE (1)
SPLICING FACTOR (1)
SPREADING DEPRESSION (1)
STRUCTURE–FUNCTION ANALYSIS (1)
SYNAPSE (1)
SYNAPTIC TRANSMISSION (1)
T-TYPE CALCIUM CHANNEL (1)
THALAMOCORTICAL CIRCUIT (1)
THALAMOCORTICAL SYSTEM (1)
TRIGEMINAL GANGLION (1)
TYROSINE KINASE (1)
VOLTAGE-DEPENDENT CALCIUM CHANNEL (1)
VOLTAGE-GATED (1)
VOLTAGE-GATED CALCIUM CHANNEL (1)
Α-CONOTOXIN (1)
Α1S (1)
Ω-CONOTOXIN (1)
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