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The whole blood interferon-γ (IFN-γ) test has proven to be a practical ancillary test for re-testing cattle for bovine tuberculosis 8-28 days following tuberculin skin testing. An improvement in the specificity of the IFN-γ test could further reduce culling of false positive animals. The primary aim of this study was to evaluate a single mycobacterial antigen, ESAT-6 in the IFN-γ test for use in skin...
In order to develop a model of Mycobacterium bovis infection with pathogenetical relevance, a modified version of the Henderson apparatus was used to deliver infectious aerosols directly to the snouts of guinea pigs. Aerosols generated from 10 6 , 10 7 , 10 8 CFU/ml M. bovis suspensions established disease in every animal, with estimated retained doses of 10, 100, 1000CFU,...
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