This study aims to assess the impact of the participation of real patients during debriefing (using patient as co-debriefer).A mixed study on the perceptions of students (n = 81) and patients as co-debriefers (n = 6) was conducted after performing simulated experiences that were directly related to the health problem.Qualitative results: valuable and enriching learning experience, harmonious and integrated co-debriefing, no preference for clinical aspects, compassion and empathy were generated, and the perception of being a therapeutic experience for patients was evident. Questionnaire results: students scored high in learning dimensions M = 14.81 (SD = 0.701), empathy M = 4.57 (SD = 0.96), positive perceptions regarding the debriefing M = 14.56 (SD = 1.09), and satisfaction M = 14.69 (SD = 0.78).This study underlines the benefits and the characteristics perceived by using real patients as co-debriefers.