This paper shows the versatility of modified charged and non-charged β-cyclodextrins in micellar systems for optically resolving β-agonists, β-antagonists, phenylethylamines stimulants and diclofensine an antidepressant. A total of 22 compounds were optically resolved using hydroxypropyl-β-cyclodextrin with sodium taurodeoxycholate and sodium sulfobutyl ether-β-cyclodextrin with sodium dodecyl sulfate.