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Biomolecular interaction is a fundamental mechanism involved in many critical biological processes including gene transcription, translation, and cell signaling networks. Many basic proteins, such as histones, transcription factors, and ribosomal proteins, participate in the interaction of these processes. Surface plasmon resonance (SPR) has been used as a “gold” standard to measure biomolecular interactions...
Asialoglycoprotein receptor (ASGP-R) has been actively investigated for targeted delivery of therapeutic agents into hepatocytes because this receptor is selectively and highly expressed in liver and has a high internalization rate. Synthetic cluster glycopeptides (e.g., triGalNAc) bind with high affinity to ASGP-R and, when conjugated to a therapeutic agent, can drive receptor-mediated uptake in...
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