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Amyloidosis producing insoluble fibrillar protein aggregates is the common pathological feature of various neurodegenerative disorders such as Parkinson’s and Alzheimer’s diseases in which α-synuclein and amyloid β/A4 protein (Aβ) participate to form Lewy bodies and senile plaques, respectively. To develop a novel analytical tool for amyloidosis, resveratrol, the major phenolic constituent of red...
The accumulation and aggregation of fragments of amyloid precursor protein (APP) are central to the development of Alzheimer’s disease. The production of the small fragment C99 is thought to form the rate-limiting step in the APP processing pathway, which can lead to the production of the toxic Aβ peptide. It has also been suggested that the proteasome contributes to APP catabolism. While the identities...
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