A successful decolorization of methylene blue (MB) was achieved through advanced Fenton's process (AFP) coupled with sonolysis (sono-AFP) using zero-valent iron (Fe 0 ) aggregate as a catalyst. The decolorization was dependent on the pH, Fe 0 , H 2 O 2 doses, and acoustic power. Fe 0 aggregate was reusable. A modified pseudo-first order equation was developed to describe the decolorization kinetics. To save electricity, short ultrasound irradiation was applied to the system. MB was completely degraded in the sono-AFP under optimized condition. The decolorization was obviously inhibited by the presence of Cl − , but it was unaffected by the presence of H 2 CO 3 , H 2 PO 4 − , ClO 4 − , NO 3 − , and SO 4 2−