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Mutations in the human filaggrin gene (FLG) are associated with atopic dermatitis (AD) and are presumed to provoke a barrier abnormality. Yet additional acquired stressors might be necessary because the same mutations can result in a noninflammatory disorder, ichthyosis vulgaris.We examined here whether FLG deficiency alone suffices to produce a barrier abnormality, the basis for the putative abnormality,...
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