In a recent Letter [R. Yang, B.H. Wang, J. Ren, W.J. Bai, Z.W. Shi, W.X. Wang, T. Zhou, Phys. Lett. A 364 (2007) 189], we proposed a modified susceptible-infected-recovered (SIR) model, in which each node is assigned with an identical capability of active contact, A, at each time step. We found a threshold value λc=1/A in uncorrelated and unlocalized networks. A corresponding Comment, raised by Alberto d'Onofrio, claimed that (i) our model is not biologically relevant; (ii) our model does not have a threshold behavior for recovered population; (iii) the analytical result λc=1/A is incorrect being considered as a threshold for epidemic outbreak, because of an improper approximation of the initial configuration. In this Reply, I show that, by debating from point to point, our analysis and conclusion are solid and reasonable.