The tribological performances of Cr/GLC film coupling with Si3N4, SiC, WC, Al2O3 and ZrO2 were comparatively studied in seawater. Results indicated that the Cr/GLC film coupling with different ceramic counterparts exhibited different friction behaviors, which was closely related to the mechanical performances of mating ceramics. Meanwhile, the tribo-chemical products between the Cr/GLC film and ceramics also played an important role in improving the tribological performances. Friction coefficient and wear rate of the Cr/GLC film sliding against Si3N4 were lower than others, which indicated that the Cr/GLC film coupled to Si3N4 ceramic exhibited optimum tribological performance in seawater.