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Psychotic patients with COMT Val158Met Met alleles were recently found to display more intense psychotic and affective responses to daily life stressors. We aimed to test the hypothesis that the Met allele is implicated in the development of affective and psychotic symptomatology in subjects genetically at risk for schizophrenia, by testing if unaffected first-degree relatives of patients...
The gene encoding catechol-O-methyltransferase (COMT), an enzyme which regulates prefrontal cortex dopamine, contains a common functional single nucleotide polymorphism (val 158 met, rs4680G/A), which accounts for part of the interindividual variance in performance during working memory tasks and also predicts personality traits.We examined the relationship between the val 158 met...
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