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An additive method has been developed to obtain nearly optically pure (S)-ketoprofen [(S)-2-(3-benzoyphenyl)propionic acid, >96% enantiomeric excess, ee] by using lipase OF (from Candida rugosa) for the first time. The effect of surfactants (selected as additives) on the enantioselective hydrolysis of 2-chloroethyl ester of ketoprofen by the crude and the purified C. rugosa lipase (lipase OF) was...
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