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Flavonoids are inactivated by phase II metabolism and occur in the body as glucuronides. Mammalian β-glucuronidase released from neutrophils at inflammatory sites may be able to deconjugate and thus activate flavonoid glucuronides. We have studied deconjugation kinetics and pH optimum for four sources of β-glucuronidase (human neutrophil, human recombinant, myeloid PLB-985 cells, Helix pomatia) with...
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