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The idea behind this work was to acquire one dimensional lasing in the Rhodamine 6G dye doped collagen fibers with the control of random lasing phenomenon properties by changing the dye molecular arrangement. We show that a simple manipulation of the dye concentration in biopolymeric fibril matrix bulk and an additional use of α-cyclodextrin (α-CD) molecules determine formation of specific dye aggregates and as a consequence the shift of the random lasing emission wavelength in the desired direction. The analysis of the light transport mean free path in function of the dye and (α-CD) concentration was done with the use of coherent back scattering technique.