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We aimed to investigate the role of K + channels and nitric oxide (NO) on the relaxant effects of arachidonic acid in the human intralobar pulmonary arteries. Arachidonic acid produced a concentration-dependent relaxation (E max =93±3% of maximal relaxation induced by papaverine 0.1 mM;−log EC 30 =7.03±0.09) that was antagonized by the cyclooxygenase inhibitor indomethacin...
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