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Membrane depolarization of airway smooth muscle (ASM) opens L-type voltage dependent Ca2+ channels (L-VDCC) allowing Ca2+ entrance to produce contraction. In Ca2+ free conditions Na+ permeates through L-VDCC in excitable and non-excitable cells and this phenomenon is annulled at µM Ca2+ concentrations. Membrane depolarization also induces activation of Gq proteins and sarcoplasmic reticulum Ca2+ release...
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