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Modulation of the reinforcing effects of cocaine and morphine by the κ-opioid receptor agonist U50,488H (trans-3,4-dichloro-N-methyl-N-(2-1-pyrrolidinyl)-cyclohexyl-benzeacetamide) was studied by using the method of intravenous (i.v.) self-administration in drug-naive Wistar rats and DBA/2 mice. Self-administration of cocaine (by rats) and morphine (by mice) was readily initiated and showed an inverted...
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