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Desensitization to serotonin (5-hydroxytryptamine, 5-HT)-facilitated dopamine release in vivo develops following either continuous or repeated pulses of 5-HT. For instance, an initial 20 min pulse of 5-HT (10 μM) produced a 715 ± 150% increase in basal dopamine, an effect which steadily declined over 5 subsequent fractions to 222 ± 80%. Also, secondary pulses (s2) of 5-HT administered 40 min following...
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