The paper demonstrates that a self-learning neurofuzzy controller is able to regulate the temperature in a liquid helium cryostat. In order to simplify the task of commissioning the controller, a strategy for choosing the user-selected parameters from an equivalent proportional-plus-integral controller (PI) is derived. Experimental results which illustrate the potential of the proposed control scheme are presented. The performance of the self-learning neurofuzzy controller is also compared with that of a commercial gain-scheduled PI controller.