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The FRAX tr algorithm uses clinical risk factors (CRF) and bone mineral density (BMD) to predict fracture risk but does not include falls history in the calculation. Using results from the Hertfordshire Cohort Study, we examined the relative contributions of CRFs, BMD and falls history to fracture prediction. We studied 2299 participants at a baseline clinic that included completion of a health...
► Faster self-perceived walking speed was associated with fewer falls and fractures in women. ► A history of falls increases fracture risk after adjustment for clinical risk factors and bone mineral density. ► Study findings accord with the recommendations of the FRAX Clinical Task Force suggesting falls are accounted for alongside FRAX.
To compare the power of FRAX® without bone mineral density (BMD) and simpler screening tools (OST, ORAI, OSIRIS, SCORE and age alone) in predicting fractures.This study was a prospective, population-based study performed in Denmark comprising 3614 women aged 40–90years, who returned a questionnaire concerning items on risk factors for osteoporosis. Fracture risk was calculated using the different...
Previous studies have shown that patients with Parkinson's disease (PD) are at increased risk of fractures. However, no specific prediction model for fracture estimation among PD patients is currently available. Therefore, the aim of this study was to develop a simple score for estimating the 5-year osteoporotic and hip fracture risks among patients with PD.The UK Clinical Practice Research Datalink...
It remains unknown why proton pump inhibitor (PPI) use may be associated with risk of osteoporotic fractures; evidence of direct effects on calcium absorption or on the osteoclast in humans is weak or absent. However, the ensuing increased gastrin levels may cause histamine production through hypertrophy of gastric enterochromaffin like cells, which could lead to bone loss. We speculated that H1 receptor...
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