Bjornson KF, Belza B, Kartin D, Logsdon RG, McLaughlin J. Self-reported health status and quality of life in youth with cerebral palsy and typically developing youth.To describe self-reported health status and quality of life (QOL) of ambulatory youths with cerebral palsy (CP) compared with sex- and age-matched typically developing youth (TDY).Prospective cross-sectional cohort comparison.Community-based.A convenience sample of 81 youth with CP (age range, 10−13y) with Gross Motor Function Classification System (GMFCS) levels I through III and 30 TDY participated. They were recruited from 2 regional children’s hospitals and 1 regional military medical center.Not applicable.Participants completed the Child Health Questionnaire−Child Form (CHQ-CF87) for health status and the Youth Quality of Life for QOL.Youth with CP reported significantly lower health status than age- and sex-matched TDY in the following CHQ-CF87 subscales: role/social behavioral physical, bodily pain, physical function, and general health (CP mean rank, 46.8−55.2; TDY mean rank, 62.2−80.9). There were significant differences across GMFCS levels. There were no significant differences in self-reported QOL.Self-reported health status, but not QOL, appears sensitive to the functional health issues experienced by ambulatory youth with CP. Pain management and psychosocial support may be indicated for them.