Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Items from 1 to 20 out of 38 results

article

Two novel missense mutations in ABCA1 result in altered trafficking and cause severe autosomal recessive HDL deficiency

Christiane Albrecht, Kevin Baynes, Alessandro Sardini, Silke Schepelmann, more

BBA - Molecular Basis of Disease > 2004 > 1689 > 1 > 47-57

Extremely low concentrations of high density lipoprotein (HDL)-cholesterol and apolipoprotein (apo) AI are features of Tangier disease caused by autosomal recessive mutations in ATP-binding cassette transporter A1 (ABCA1). Less deleterious, but dominantly inherited mutations cause HDL deficiency. We investigated causes of severe HDL deficiency in a 42-year-old female with progressive coronary disease...

article

Low magnesium promotes endothelial cell dysfunction: implications for atherosclerosis, inflammation and thrombosis

Jeanette A.M. Maier, Corinne Malpuech-Brugère, Wioletta Zimowska, Yves Rayssiguier, more

BBA - Molecular Basis of Disease > 2004 > 1689 > 1 > 13-21

Because (i) endothelial cells are important players in cardiovascular diseases and (ii) Mg deficiency promotes atherosclerosis, thrombosis and hypertension, we evaluated whether low concentrations of Mg could directly affect endothelial behavior. We found that low Mg concentrations reversibly inhibit endothelial proliferation, and this event correlates with a marked down-regulation of the levels of...

article

Products of lipid peroxidation induce missorting of the principal lysosomal protease in retinal pigment epithelium

George Hoppe, June O'Neil, Henry F. Hoff, Jonathan Sears

BBA - Molecular Basis of Disease > 2004 > 1689 > 1 > 33-41

Phagocytosis of photoreceptor outer segments (OS) by retinal pigment epithelium (RPE) is essential for OS renewal and survival of photoreceptors. Internalized, oxidatively modified macromolecules perturb the lysosomal function of the RPE and can lead to impaired processing of photoreceptor outer segments. In this study, we sought to investigate the impact of intracellular accumulation of oxidatively...

article

Editorial Board

BBA - Molecular Basis of Disease > 2004 > 1689 > 1 > ii

article

Calcium phosphate and calcium oxalate crystal handling is dependent upon CLC-5 expression in mouse collecting duct cells

J.A. Sayer, G. Carr, N.L. Simmons

BBA - Molecular Basis of Disease > 2004 > 1689 > 1 > 83-90

Defects in an intracellular chloride channel CLC-5 cause Dent's disease, an inherited kidney stone disorder. Using a collecting duct model, mIMCD-3 cells, we show expression of dimeric mCLC-5. Transient transfection of antisense CLC-5 reduces CLC-5 protein expression. Binding of both calcium phosphate (hydroxyapatite) and calcium oxalate monohydrate (COM) crystals overlaid onto mIMCD-3 cultures was...

article

Splicing alterations in human renal allografts: detection of a new splice variant of protein kinase Par1/Emk1 whose expression is associated with an increase of inflammation in protocol biopsies of transplanted patients

Miguel Hueso, Violeta Beltran, Francesc Moreso, Eva Ciriero, more

BBA - Molecular Basis of Disease > 2004 > 1689 > 1 > 58-65

Protein kinase Emk1/Par1 (GenBank accession no. X97630) has been identified as a regulator of the immune system homeostasis. Since immunological factors are critical for the development of chronic allograft nephropathy (CAN), we reasoned that expression of Par1/Emk1 could be altered in kidney allografts undergoing CAN. In this paper, we have analysed the association among renal allograft lesions and...

article

Publisher's Announcement

BBA - Molecular Basis of Disease > 2004 > 1689 > 1 > v

article

H3 mRNA level as a new proliferative marker in astrocytomas

Joanna Orchel, Jerzy Slowinski, Urszula Mazurek, Tadeusz Wilczok

BBA - Molecular Basis of Disease > 2004 > 1689 > 1 > 42-46

Replication-dependent H3.1 and H3.2 histones are encoded by 11 genes. The H3 mRNA levels in brain astrocytomas using real-time RT-PCR assay was examined. The sequence of primers and probe used in amplification was designed basing on the reference sequence GenBank accession no. Z83737. The H3 mRNA levels correlated with tumor grade (R=0.56, P=0.0012), Ki-67 proliferative antigen labeling index (R=0...

article

Identification of hepatic molecular mechanisms of action of alpha-tocopherol using global gene expression profile analysis in rats

Luca Barella, Patrick Y. Muller, Manfred Schlachter, Willi Hunziker, more

BBA - Molecular Basis of Disease > 2004 > 1689 > 1 > 66-74

The recent discovery that vitamin E (VE) regulates gene activity at the transcriptional level indicates that VE may exert part of its biological effects by mechanisms which may be independent of its well-recognised antioxidant function. The objective of this study was the identification of hepatic vitamin E-sensitive genes and examination of the effects of VE on their corresponding biological endpoints...

article

The role of interleukin-10 in the regulation of the systemic inflammatory response following trauma-hemorrhage

Christian P. Schneider, Martin G. Schwacha, Irshad H. Chaudry

BBA - Molecular Basis of Disease > 2004 > 1689 > 1 > 22-32

Pro-inflammatory cytokine release after shock is central in the development of subsequent multiple organ dysfunction syndrome. Some studies suggest that interleukin-10 (IL-10) is an immunosuppressive mediator after injury or sepsis, while others suggest that IL-10 is an important regulator of the pro-inflammatory response. We hypothesized that in a model of trauma and hemorrhagic shock (TH), IL-10...

article

Air pollutants increase gene expression of the vasoconstrictor endothelin-1 in the lungs

Errol Thomson, Patrick Goegan, Prem Kumarathasan, Renaud Vincent

BBA - Molecular Basis of Disease > 2004 > 1689 > 1 > 75-82

Inhalation of urban pollutants elevates the circulating levels of the vasoactive peptides endothelin (ET)-1 and ET-3 in rats. This effect could explain the association between episodic variations of urban pollutants and acute cardiopulmonary morbidity and mortality documented in epidemiological studies. Because the lungs are the primary source of circulating ET-1 and the main site of clearance from...

article

The prion-like protein Doppel fails to interact with itself, the prion protein and the 37 kDa/67 kDa laminin receptor in the yeast two-hybrid system

Christoph Hundt, Stefan Weiss

BBA - Molecular Basis of Disease > 2004 > 1689 > 1 > 1-5

The prion-like protein termed Doppel (Dpl) shows approx. 25% sequence identity with all known prion proteins (PrP). We recently showed that the cellular PrP is dimeric under native conditions, a finding which was confirmed by the investigation of its crystal structure. Human PrP further interacts with its cellular receptor, the 37 kDa/67 kDa laminin receptor (LRP/LR). Here we report that human Doppel...

article

High concentrations of magnesium modulate vascular endothelial cell behaviour in vitro

Jeanette A.M. Maier, Daniela Bernardini, Yves Rayssiguier, Andrzej Mazur

BBA - Molecular Basis of Disease > 2004 > 1689 > 1 > 6-12

Magnesium supplementation has been reported to prevent cardiovascular diseases through the decrease of plasma lipids and to improve endothelial function in patients with coronary artery disease. In the present work, we evaluated whether high magnesium concentrations can directly affect the function of cultured endothelial cells, which play a crucial role in maintaining the functional integrity of...

article

Impaired mitochondrial respiratory chain and bioenergetics during chagasic cardiomyopathy development

Galina Vyatkina, Vandanajay Bhatia, Arpad Gerstner, John Papaconstantinou, more

BBA - Molecular Basis of Disease > 2004 > 1689 > 2 > 162-173

In this study, we evaluated the activities of respiratory chain complexes and oxidative phosphorylation (OXPHOS) capacity of the heart to gain insights into the pathological significance of mitochondrial dysfunction in chagasic cardiomyopathy (CCM). In a murine model of Trypanosoma cruzi infection, biochemical and histochemical analysis of the cardiac mitochondria revealed deficiency of the respiratory...

article

Fluoride-induced changes to proteoglycan structure synthesised within the dentine-pulp complex in vitro

R.J. Waddington, R. Moseley, A.J. Smith, A.J. Sloan, more

BBA - Molecular Basis of Disease > 2004 > 1689 > 2 > 142-151

Fluoride is known to influence mineralisation patterns within dentine, where alterations in the post-translational modification of proteoglycans (PG) have been proposed as an implicating factor. In light of recent studies elucidating changing PG profiles in the transition of predentine to mineralised dentine, this study investigates the influence of fluoride on the major PG populations (decorin, biglycan...

article

Matrix proteoglycans are markedly affected in advanced laryngeal squamous cell carcinoma

Spyros S. Skandalis, Achilleas D. Theocharis, Dimitrios A. Theocharis, Theodoros Papadas, more

BBA - Molecular Basis of Disease > 2004 > 1689 > 2 > 152-161

Proteoglycans (PGs) are implicated in the growth and progression of malignant tumors. In this study, we examined the concentration and localization of PGs in advanced (stage IV) laryngeal squamous cell carcinoma (LSCC) and compared with human normal larynx (HNL). LSCC and HNL sections were examined immunohistochemically with a panel of antibodies, and tissues extracts were analyzed by biochemical...

article

Differential expression of thyroperoxidase mRNA splice variants in human thyroid tumors

Valérie Le Fourn, Mireille Ferrand, Jean-Louis Franc

BBA - Molecular Basis of Disease > 2004 > 1689 > 2 > 134-141

The levels of human thyroperoxidase (hTPO) mRNA expression and the rates of hTPO mRNA with alternatively spliced exons 10, 14, and 16 were analyzed in normal, benign, and malignant thyroid tissues (13 normal thyroid tissues, 9 adenomas, 4 papillary carcinomas, 11 follicular variant of papillary carcinomas, 16 minimally invasive follicular carcinomas, 6 widely invasive follicular carcinomas) using...

article

Cysteamine prevents and reverses the inhibition of pyruvate kinase activity caused by cystine in rat heart

Tatiana Galetto Rosa, Angela Terezinha de Souza Wyse, Moacir Wajner, Clóvis Milton Duval Wannmacher

BBA - Molecular Basis of Disease > 2004 > 1689 > 2 > 114-119

Cystinosis is a disorder associated with excessive lysosomal cystine accumulation secondary to defective cystine efflux. Patients affected by this disease develop a variable degree of symptoms depending on the involved tissues. Accumulation of cystine in myocardium may lead to heart failure. However, the mechanisms by which cystine is toxic to the tissues are not fully understood. Considering that...

article

Identification of changes in the transcriptome profile of human hepatoma HepG2 cells stimulated with interleukin-1 beta

Jolanta Jura, Paulina Węgrzyn, Adrian Zarębski, Benedykt Wl̷adyka, more

BBA - Molecular Basis of Disease > 2004 > 1689 > 2 > 120-133

Interleukin-1 (IL-1) is the principal pro-inflammatory cytokine participating in the initiation of acute phase response. Human hepatoma HepG2 cells were exposed to 15 ng/ml of IL-1beta for times ranging from 1 to 24 h and the total RNA was isolated. Then cDNA was obtained and used for differential display with 10 arbitrary primers and 9 oligo(dT) primers designed by Clontech. Validation of observed...

article

Editorial Board

BBA - Molecular Basis of Disease > 2004 > 1689 > 2 > ii

Volume:
1689
Year:
2004

Publication date

Set your own date range

Number

3 (16)
2 (9)
1 (13)

Keywords

ATHEROSCLEROSIS (2)
CARDIOMYOPATHY (2)
ENDOTHELIAL CELL (2)
GENE EXPRESSION (2)
LIPID PEROXIDATION (2)
MAGNESIUM (2)
GDCL 2 (1)
37 KDA/67 KDA LAMININ RECEPTOR (1)
8-ISOPROSTANE (1)
ABCA1 (1)
ACUTE PHASE PROTEIN (1)
ADRENOLEUKODYSTROPHY (1)
ADVANCED GLYCATION END-PRODUCT (1)
AIR POLLUTION (1)
ANGIOTENSIN-(1–7) (1)
ANGIOTENSIN-CONVERTING ENZYME 2 (1)
ANTI-IL-10 (1)
ANTIFOLATE CB 3717 (1)
ANTIOXIDANT (1)
AOPP (1)
APOLIPOPROTEIN AI (1)
APOLIPOPROTEIN E (1)
APOPTOSIS (1)
ASTROCYTOMA (1)
AUTOIMMUNE HEPATITIS (1)
BANFF 97 SCHEMA (1)
C-MYC (1)
CALCIUM PHOSPHATE (1)
CALSEQUESTRIN (1)
CANCER (1)
CARBONIC ANHYDRASE (1)
CARDIOVASCULAR DISEASE (1)
CASPASE-10 (1)
CATECHOLAMINES (1)
CATHEPSIN D (1)
CECAL LIGATION AND PUNCTURE (1)
CHAGASIC CARDIOMYOPATHY (1)
CHAPERONE (1)
CHLORIDE CHANNEL (1)
CHOLESTEROL EFFLUX (1)
CHRONIC ALLOGRAFT NEPHROPATHY (CAN) (1)
CIRRHOSIS (1)
CISPLATIN (1)
CLC-5 (1)
COLLECTING DUCT (1)
COM CRYSTAL (1)
COMPLEMENT ACTIVATION (1)
CROSS-TALK (1)
CRYPTIC EXON (1)
CYSTEAMINE (1)
CYSTINE (1)
CYSTINOSIS (1)
CYTOKINE (1)
DENT'S DISEASE (1)
DENTINE (1)
DIABETIC (1)
DIABETIC RETINOPATHY (1)
DIFFERENTIAL DISPLAY (1)
DITYROSINE (1)
DNA ARRAY (1)
DOMINANT NEGATIVE EFFECT (1)
DOPAMINE Β-HYDROXYLASE (1)
DOPPEL (1)
DPL (1)
DUAL POLARIZATION INTERFEROMETRY (1)
DYSTROPHIN (1)
ENDOCYTOSIS (1)
ENDOTHELIN-1 (ET-1) (1)
ENDOTHELIN-CONVERTING ENZYME-1 (ECE-1) (1)
FINGER MILLET (1)
FLUORIDE (1)
FREE RADICAL (1)
GAUCHER DISEASE (1)
GLUCOSYLCERAMIDE (1)
GLYCOSAMINOGLYCAN (1)
HALF ABC TRANSPORTER (1)
HDL (1)
HDL DEFICIENCY (1)
HEART (1)
HEART FAILURE (1)
HEMODIALYSIS (1)
HGF/C-MET (1)
HISTONE GENE (1)
HUMAN (1)
IMMUNE RESPONSE (1)
INDUCIBLE GENE EXPRESSION (1)
INFLAMMATION (1)
INFLAMMATORY TRANSCRIPTOME (1)
INTEGRIN Β1 (1)
KIDNEY ALLOGRAFT (1)
KUPFFER CELL (1)
LARYNGEAL CANCER (1)
LDL (1)
LIGAND (1)
LIVER (1)
LRP/LR (1)
LYSOSOME (1)
MDX (1)
MECHANISM (1)
MELANOCORTIN-3 RECEPTOR (1)
more

INFONA - science communication portal

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Two novel missense mutations in ABCA1 result in altered trafficking and cause severe autosomal recessive HDL deficiency

Low magnesium promotes endothelial cell dysfunction: implications for atherosclerosis, inflammation and thrombosis

Products of lipid peroxidation induce missorting of the principal lysosomal protease in retinal pigment epithelium

Editorial Board

Calcium phosphate and calcium oxalate crystal handling is dependent upon CLC-5 expression in mouse collecting duct cells

Splicing alterations in human renal allografts: detection of a new splice variant of protein kinase Par1/Emk1 whose expression is associated with an increase of inflammation in protocol biopsies of transplanted patients

Publisher's Announcement

H3 mRNA level as a new proliferative marker in astrocytomas

Identification of hepatic molecular mechanisms of action of alpha-tocopherol using global gene expression profile analysis in rats

The role of interleukin-10 in the regulation of the systemic inflammatory response following trauma-hemorrhage

Air pollutants increase gene expression of the vasoconstrictor endothelin-1 in the lungs

The prion-like protein Doppel fails to interact with itself, the prion protein and the 37 kDa/67 kDa laminin receptor in the yeast two-hybrid system

High concentrations of magnesium modulate vascular endothelial cell behaviour in vitro

Impaired mitochondrial respiratory chain and bioenergetics during chagasic cardiomyopathy development

Fluoride-induced changes to proteoglycan structure synthesised within the dentine-pulp complex in vitro

Matrix proteoglycans are markedly affected in advanced laryngeal squamous cell carcinoma

Differential expression of thyroperoxidase mRNA splice variants in human thyroid tumors

Cysteamine prevents and reverses the inhibition of pyruvate kinase activity caused by cystine in rat heart

Identification of changes in the transcriptome profile of human hepatoma HepG2 cells stimulated with interleukin-1 beta

Editorial Board

Filter options

Publication date

Number

Keywords

INFONA - science communication portal

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Number

Keywords

Reporting an error / abuse

Sending the report failed

Accessibility options