O-Aryloxime ether analogues L1–L3 were studied as ligands in palladium-catalyzed Suzuki–Miyaura cross-coupling reaction of aryl bromides and aryl boronic acids in water at room temperature. Reaction conditions for the cross-coupling were optimized using PdCl 2 and Pd(OAc) 2 under aerobic condition. From the three electronically diverse O-aryloxime ether ligands studied herein, the use of 1-phenyl-ethanone O-(4-chloro-phenyl)-oxime L2 exhibits the best catalytic system in the presence of K 2 CO 3 as the base and TBAB as the promoter.