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Due to their low skin permeabilities, transdermal transport of hydrophilic solutes is poorly understood. In this study, we sought to determine the dependence of solute tortuosity on solute size and stratum corneum (SC) porosity. With porous pathway model, transdermal transport of hydrophilic solutes through the SC was modeled as diffusion through imperfections/defects that occur between/within the...
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