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A silicone based matrix containing dispersed medicated granules of a crosslinked polyethylene glycol with high swelling capacity is evaluated for its potential to release in vitro substantial fractions of drugs of different solubilities within 6 hours at controlled rates. Papaverine- HCl, clonidine- HCl and salicylamide are the model drugs. With a matrix shape of a 0.1-cm thick disc, a weight fraction...
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