Combination of CdSe quantum dots (QDs) and silicone resin is of technical significance due to their individual merits. In this article, multifunctional transparent CdSe-QD/silicone nanocomposites with tunable emission colors are prepared by uniformly dispersing CdSe-QDs in a transparent silicone resin via a facile solution-mixing method. The photo-luminescent properties of the novel CdSe-QD/silicone nanocomposites are investigated as a function of CdSe-QD size and content. The homogeneous dispersion of CdSe-QDs leads to a good transparency of the nanocomposites. The as-designed and prepared nanocomposites show interesting luminescent properties with different colors and emit lights with a wide peak wavelength range from 501 to 582nm.