A series of Ni/SBA-15 catalysts with Ni contents from 7.5 wt% to 15 wt% were prepared by impregnation method. The effect of O 2 and H 2 O on the combined reforming of the simulated biogas to syngas was investigated in a continuous flow fixed-bed micro-reactor. The stability of the catalyst was tested at 800 °C. The results indicated that 10wt%Ni/SBA-15 catalyst exhibited the highest catalytic activities for the combined reforming of the simulated biogas to syngas. Under the reaction conditions of the feed gas molar ratios CH 4 /CO 2 /O 2 /H 2 O = 2/1/0.6/0.6, GHSV = 24000 ml·g cat −1 ·h −1 and the reaction temperature T = 800 °C, the conversions of CH 4 and CO 2 were 92.8% and 76.3%, respectively, and the yields of CO and H 2 were 99.0% and 82.0%, respectively. The catalytic activities of the catalyst did not decrease obviously after 100 h reaction time on stream.