Ciprofloxacin, one of the fluoroquinolone antibiotics, has become one of the most widely prescribed antimicrobial agents. It is generally well tolerated with a low incidence of side effects, which are mild in nature. There is a distinct incidence of neuropsychiatric adverse effects, which include psychotic reactions. We describe a case of a woman who experienced an acute psychosis secondary to ciprofloxacin administration, which resolved on cessation of therapy. All urologists should be aware of this problem and be familiar with the recommendations for ciprofloxacin use in patients with underlying neuropsychiatric problems.