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Glutamate, the endogenous neurotransmitter at the NMDA receptor, and cysteinylglycine are formed as byproducts of glutathione (GSH) metabolism by γ-glutamyltranspeptidase. Glutamate and cysteinylglycine were investigated in Fura-2-loaded whole-brain neonatal (< 24 h) dissociated neurons to determine 1) if cysteinylglycine might act as a glycine site coagonist, 2) the inhibitory effects of ethanol...
Experiments were carried out in which a nutritionally balanced liquid diet previously used in this laboratory was modified as to total calorie content and high or low carbohydrate and fat concentration. Ethanol was added at 4.5% and 6.2% of diet weight and provided either 27% or 34-37% of total calories depending upon the changes in nutrient content. Measurements included 8-day food/calorie and...
The composition of 36 amino acids and related amino compounds is presented for plasma, aorta, heart, pancreas, and bronchi. The distribution pattern of these biochemicals is similar but not identical among the tissues. The effect of an acute dose of ethanol (2 g/kg, IP) on these amino acids and related compounds was then studied. In the plasma, alanine, arginine, aspartic acid, beta-alanine, glycine,...
Proton and phosphorous NMR spectroscopy were used to study a model membrane system consisting of reversed lipid micelles to test the hypothesis that alcohol and anesthetics compete with water for the same hydrogen bonding sites on lipid surfaces. When low concentrations of water and ethanol were added in equal parts in the absence of lipid and nonpolar solvent, the NMR spectrum consisted of a combination...
Over the last 30 years, acetaldehyde has been postulated to mediate various actions of ethanol on the brain. Experiments have studied ethanol consumption after acetaldehyde infusions into the brain, in rodents with high or low activities of hepatic and brain ethanol-metabolizing enzymes, and after treatment with drugs that after the metabolism of acetaldehyde after ethanol ingestion. Evidence that...
This section of the journal is designed to provide readers with reviews of recent literature, and to stimulate research on questions that are important in the treatment and prevention of alcohol addiction. Research can provide insight into the causes of alcohol abuse and addiction, as well as answers to questions concerning the biomedical and psychological consequences of alcohol consumption. The...
Depending on the situation, ethanol can serve as a reinforcer in one paradigm and an aversive stimulus in another. The relationships between the two stimuli are not clear, particularly the behavioural adaptation following chronic ethanol exposure. We report on two experiments using an oral-self administration (OSA) paradigm and a conditioned taste aversion (CTA) paradigm. Male Wistar rats were...
Three experiments examined the effects of the training-to-testing interval on alcohol aversions. In Experiments 1 and 2, rats learned a taste aversion to a 4% (v/v) alcohol solution using lithium chloride as the illness agent. With a between-groups design, subjects were tested with 1%, 4%, or 7% alcohol, beginning either 2 or 21 days after training. In both experiments, results showed that rats...
The effects of environmental enrichment on synaptic spine density in hippocampal area CA1 were examined in rats exposed prenatally to alcohol. Pregnant dams were given ethanol via intragastric intubation (6 g/kg/day) from gestational days 8 through 19, or given isocaloric sucrose. An untreated control group was also used. After weaning, offspring from the three groups were then reared for 10 weeks...
The effects of moderate, short-term ethanol (EtOH) intake on various physiololgical parameters in growth-selected, juvenile, meat-type chickens were determined. Ethanol (20%) was administered orally at 2 ml per kg of body weight three times daily between 21 and 28 days of age. Feed consumption, body weight, rectal temperature, relative weights of the thyroid, adrenal, pancreas, and liver, serum...
The importance of temporal factors on the presence and severity of ethanol withdrawal signs in the rat was quantified using rating scale, tremor, and acoustic startle paradigms. Ethanol dependence was induced in naive male Wistar rats by liquid diet administration (n = 21) or vapor inhalation (n = 13). Subjects were analyzed for intensity and duration of physiological ethanol dependence in repeated-measures...
Using choleratoxin/antitoxin immunohistochemistry, this study examined the effects of in vitro alcohol exposure on the morphology of cell plasma membranes in mixed fetal rat cortical cultures, and assessed the neuroprotective effects of exogenous monosialoganglioside (GM1). Gangliosides are involved in critical biological functions, including maintenance of membrane integrity. Plasma membranes are...
Hypothermia and ethanol are often closely linked and in hypothermic accidents ethanol is often a contributing factor. To study the effects of ethanol on the circulation in hypothermic conditions, cardiac catherization was carried out on 18 anaethetized beagle dogs. They were divided into two groups. One gram of ethanol/kg of b.wt. diluted in saline was infused into the vena cava superior within...
Owing to the clinical similarity between the male climacteric syndrome and the results of previous studies on the alcohol withdrawal syndrome in relation to sex hormones, we hypothesized that alcoholics with a poor supply of testosterone will develop more pronounced symptoms during alcohol withdrawal than alcoholics with high levels of testosterone. Fifty-two male alcoholics were studied. To test...
Effects of ethanol (0.55 g/kg) and auditory distraction on visual forced choice reaction time (RT) were investigated in 10 healthy social drinkers, using a single-blind, placebo-controlled, crossover design. Subjects were to respond by pressing a button either with their right-hand index or middle finger, depending on whether an odd or an even digit was presented on a PC screen. In control blocks,...
Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are the principal enzymes responsible for the oxidation of ingested ethanol in humans. To study these two enzymes in surgical specimens of attached gingiva and tongue, we have examined the isozyme patterns by agarose isoelectric focusing and determined the enzyme activities. Class IV μ-ADH, class III χ-ADH, and class III ALDH 3 ...
This study was performed to delineate the combined effects of a low-fat diet and chronic ethanol ingestion on collagen metabolism in rat pancreas. Rats fed a very low-fat diet (5% of total calories as lipid) for 12 weeks developed malnutrition as judged by weight loss (-33% of the initial body weight) and low serum albumin and amylase levels. The pancreas of malnourished rats showed increased collagenase...
The purpose of the present study was to determine the effects of an angiotensin II (AII) AT 1 antagonist, losartan 10, 15, and 20 mg/kg IP, and the AII AT 2 antagonist, PD 123319, 20 mg/kg IP on ethanol (EtOH) intoxication as measured by the aerial righting reflex in male rats. EtOH (25%), 2.0 g/kg, was administered by stomach tube under mild metaphane anesthesia and the aerial righting...
This study examines the effect of alcohol withdrawal on lipoprotein(a) [Lp(a)] in 24 male, middle-aged chronic alcohol abusers admitted for withdrawal therapy. Serum concentration of Lp(a) was determined before and during the first 3 weeks of abstinence. The changes in three sialylated proteins [Lp(a), α1-antitrypsin (α1-AT), and haptoglobin (Hp)] and in desialylated transferrin (CDT) were also...
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