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In a sample of 149 emergency surgical patients, binge drinking was assessed through interviews. Sensitivity, specificity, and positive and negative predictive values were calculated for three questionnaires-the Malmo modification of brief MAST (Mm-MAST), CAGE, and the Trauma Scale-and two biological markers-carbohydrate-deficient transferrin (CDT) and gamma-glutamyltransferase (GGT). Binge drinking...
The [ 14 C]-2-deoxyglucose ([ 14 C]-2-DG) quantitative autoradiographic technique was used to determine rates of local cerebral glucose utilization (LCGU) in discrete brain regions of adult, male alcohol-preferring (P) rats after 2 weeks of ethanol deprivation (E-D), 3 and 14 days of ethanol-relapse drinking (E-R3; E-R14), and in P rats, which were chronically drinking ethanol...
Naltrexone, an opioid antagonist, has been shown to reduce the palatability of 10% alcohol solutions in rats, as measured by taste reactivity. In the present study, the effect of acute naltrexone treatment on taste reactivity to a variety of taste solutions and concentrations was tested to determine whether naltrexone has generalized effects on taste responsiveness. Thirty minutes before a taste reactivity...
The anxiolytic effect of ethanol is generally accepted to be involved in the development of alcohol dependence. Because serotonin (5-HT) is said to be involved in both anxiety and alcohol dependence, in the present study the effect of acute ethanol administration on basal 5-HT release of the medial prefrontal cortex and its effect on 5-HT release in rats submitted to an animal model of anxiety, the...
In vitro, ethanol in combination with acetaminophen induces hepatocyte apoptosis resembling immune-mediated fulminant hepatic failure in human beings. Intracellular pathways originating at the mitochondria are linked to apoptosis. I studied ethanol-induced apoptosis and hepatocytotoxicity after using an in vitro model of normal human primary hepatocytes that were exposed to 5 or 10 mM acetaminophen,...
Daily self-reports on six dimensions of mental well-being, with the use of the Swedish Mood Adjective Check List (sMACL), were investigated in 61 socially stable and physically and mentally healthy subjects with long-term excessive alcohol consumption (113 +/- 42 g of pure alcohol daily) during a 7-week study. At the start of the study, all subjects had low levels of mental well-being compared with...
This study is based on a consecutive series of 52 male alcoholics who have been followed up for 4 years after inpatient detoxification. The aim was to identify risk factors for readmission for alcohol detoxification. Information was collected individually, and psychiatric status, physiologic conditions at admission, personality profile, platelet monoamine oxidase (MAO) activity level, current psychosocial...
This study was designed to investigate whether a carrier-dependent mechanism is involved in ethanol-induced dopamine release in vitro. Rat nucleus accumbens slices were incubated with [ 3 H]dopamine in the presence of pargyline and then superfused. Spontaneous [ 3 H]dopamine release was unaffected by addition of tetrodotoxin or withdrawal of calcium, but was increased significantly...
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