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•Epigenetic modifications change global gene expression in response to environmental factors.•Alcohol consumption can affect the epigenome across the lifespan and generations.•Further research into epigenetic changes may allow for identification of biomarkers and creation of novel therapeutics.
Chronic alcohol exposure produces widespread neuroadaptations and alterations in gene expression in human alcoholics and animal models. Technological advances in the past decade have increasingly highlighted the role of non-protein-coding RNAs (ncRNAs) in the regulation of gene expression and function. These recently characterized molecules were discovered to mediate diverse processes in the central...
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