The compressibilities of disordered pyrochlores NaCaMg 2 F 7 and NaCdZn 2 F 7 (both Fd3¯m, Z=8) have been studied with X-ray single-crystal and powder diffraction using diamond anvil cells to 6.5 and 9.0GPa at room temperature, respectively. The compressibility data are fitted with the Murnaghan equations of state. The zero-pressure bulk modulus B 0 and the unit-cell volume at ambient pressure V 0 (for the fixed first pressure derivative of the bulk modulus B′=4.00) are equal to 83(2)GPa and 1107.12(1.33)Å 3 for NaCdZn 2 F 7 and to 83(5)GPa and 1079.29(2.62)Å 3 for NaCaMg 2 F 7 . Upon decreasing the unit-cell volume, the positional x parameter of the F(2) atom increases in NaCdZn 2 F 7 but is constant in NaCaMg 2 F 7 . In both cases, the (Na,Cd)F 8 and (Na,Ca)F 8 cubes become more regular and are softer than the ZnF 6 and MgF 6 octahedra, respectively. Both materials are structurally stable at least to the respective highest pressures reached in this study. These observations are compared to the high-pressure behavior of oxide pyrochlores.