Whisker reinforcement can enhance the thermal shock resistance of coating. Here, a mullite whisker-toughened silicate glass coating for SiC pre-coated carbon/carbon composites (SiC-C/C) was prepared by a molten salt and hot dipping method. The microstructure, interface bonding strength and thermal shock resistance of the coating were investigated. Results show that preparing the buffer mullite whisker layer and incorporating the mullite whisker can effectively improve the coating interface bonding and decrease the size of microcracks. The as-prepared coating has an enhanced thermal shock resistance and the weight loss of the coated samples was only 2.21% after 100 thermal cycles.