In this paper, we study a class of nonlinear operator equations with more extensive conditions in ordered Banach spaces. By using the cone theory and Banach contraction mapping principle, the existence and uniqueness of solutions for such equations are investigated without demanding the existence of upper and lower solutions and compactness and continuity conditions. The results in this paper are applied to a class of abstract semilinear evolution equations with noncompact semigroup in Banach spaces and the initial value problems for nonlinear second-order integro-differential equations of mixed type in Banach spaces. The results obtained here improve and generalize many known results.