Researchers analysing gender differences in the pharmacodynamics and pharmacokinetics of neuroleptic drugs have reported better overall improvement of psychosis in women compared with men and generally higher drug plasma levels in female patients. (Yonkers et al. 1992) * .In this study, Brief Psychiatric Rating Scale (BPRS) data on 19 male and 21 female psychotic patients was correlated with medication, demographic and general diagnostic information. BPRS item scores for time points nearest admission (pre-treatment) were compared with scores nearest discharge (post-treatment). Drug information was collated from drug charts and considered in chlorpromazine dose equivalent. Females received higher doses of neuroleptics in mg/kg of body weight compared with males. Paired t-tests revealed significant (p<0.01) improvement between pre- and post-treatment BPRS scores in males for symptoms of conceptual disorganisation, tension, suspiciousness, hallucinations and unusual thought content. In females, there was significant improvement in the symptoms of conceptual disorganisation, hostility and unusual thought content.Overall, males responded better across a larger number of symptoms compared with females. Our findings suggest that females received generally higher doses of neuroleptics without significant benefits.