In this pilot study the authors set out to: (a) describe the incidence of taste changes associated with intravenous (IV) pentamidine treatment; and (b) determine the factors that are related to making the taste changes better and worse. A convenience sample (N=18) of adult male outpatients with AIDS participated in this study. One hundred percent of the participants experienced an unpleasant taste after the administration of pentamidine. The largest percentage of patients had a metallic taste (89%, n=16); while 67% (n=12) experienced a bitter taste. These data suggest that healthcare providers need to assess for the unpleasant taste associated with IV pentamidine and develop appropriate management strategies.