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Pituitary tumors occur sporadically (95%) or as hereditary tumors, either associated with endocrine syndromes (2.5%) or as familial isolated variants (FIPA, 2.5%). In sporadic pituitary tumors, in addition to the known somatotropic GNAS mutation, a recurrent mutation of the USP8 gene was recently detected in corticotropinomas. Thus variable genetic and epigenetic modifications may mostly be responsible...
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