Mn contained (Ti-)HMS catalysts were synthesized by in situ method using manganese acetate as Mn source. The samples were characterized by a series of techniques including XRD, N2 sorption, UV-vis, FT-IR and TEM, and their catalytic performance were tested in oxidative decolorization of methylene blue (MB) or rhodamine B (RhB) in model wastewater. Mn/Ti-HMS(50) as an optimized sample maintained highly ordered mesopores and uniform pore size distribution. Mn/Ti-HMS(50) obtained high removal and conversion of the dyes by using a small scale of H2O2 via the Fenton-like process. In this bimetallic catalyst, Mn2+ acted as the main active sites to generate most of the hydroxyl radicals for Fenton process, and the framework Ti gave an obvious promotion effect. A comparative study showed that Mn/Ti-HMS(50) obtained higher removal for MB, especially for RhB in more moderate conditions than Fe/Ti-HMS. Mn/Ti-HMS(50) was able to be reused for more than 3 times in decolorization of MB, but deactivated in decolorization of RhB. The spent catalyst can be effectively regenerated by calcination.