The aim of this study is to determine the clinical usefulness of pulse wave velocity of the aorta (PWV), blood flow velocity of the common carotid artery (Velocity), ankle pressure index (API), serum thrombomodulin (Tm), serum lipoprotein(a) (Lp(a)), as clinical indicators for cardiovascular disease. Velocity was measured using a QFM-110 ultrasonic blood flow meter (Hayashi Denki Co., Ltd.) and PWV was measured using a PWV-200 (Fukuda Denki Co., Ltd.). We studied 209 outpatients (114 males and 95 females), aged 25 to 91 years. The subjects were divided into four groups; subjects with cerebrovascular disease (lacunar infarction or transient ischemic attack) (group A), subjects with ischemic heart disease (myocardial infarction or angina pectoris) (group B), subjects with both cerebrovascular accident and ischemic heart disease (group C), and subjects with neither cerebrovascular accident nor ischemic heart disease (Group D). There were no significant difference of serum lipids, Lp(a), Tm, and API between four groups. PWV was significantly higher in Group B and C than in group A and D. Velocity was significantly lower in Group B and C than group A and D. Significant positive correlation was found between PWV and age (r = 0.406, p < 0.001). Significant negative correlation was found between Velocity and age (r = -0.401, p < 0.001). On multiple regression analysis, age was the independent variables for cerebrovascular accident and only PWV was the independent variables for ischemic heart disease.In conclusion, PWV was an useful clinical marker for ischemic heart disease. However, there was no useful clinical markers for cerebrovascular disease in this study.